Towards early dental caries detection with OCT and polarized Raman spectroscopy
نویسندگان
چکیده
In recent years, we have been developing optical coherence tomography (OCT) and polarized Raman spectroscopy (PRS) for the detection of early noncavitated dental caries. OCT provides high resolution morphological depth imaging of incipient caries. With OCT, early lesions can be readily identified as regions of high light backscattering with depth into the enamel as compared to health sound enamel. From the OCT images, the lesion depth can be approximated to provide clinically useful information to guide treatment decisions. In addition, we have derived a parameter known as the optical attenuation coefficient in order to distinguish sound from carious enamel non-subjectively. OCT is being combined with PRS since regions of high light backscattering not related to caries development can lead to false-positive results. PRS provides biochemical specificity along with molecular structural/orientational information. With PRS, the Raman depolarization ratio calculated from the main phosphate vibration at ~959 cm from paralleland cross-polarized Raman spectra allows discrimination between sound and early developing caries. Early studies on lab bench instrumentation are now being translated into fibre-optic based devices for intra-oral use in patient volunteers for clinical validation. In combination, OCT and PRS have potential for detecting and monitoring early lesions with high sensitivity and high specificity.
منابع مشابه
Diagnosis of Tooth Decay Using Polarized Micro-raman Confocal Spectroscopy
The tooth enamel presents a Raman spectrum with strong polarization anisotropy. Carious lesions of the enamel will produce an alteration of local symmetry. This will reduce the anisotropy of the Raman spectra. Thus micro-Raman polarized spectroscopy could be a used in early detection of teeth caries.
متن کاملArrayed Waveguide Grating for Polarized Raman Spectroscopy of Human Teeth
We designed an arrayed-waveguide grating spectrometer for the detection of early dental caries in teeth through polarized Raman spectroscopy. Measurement results on extracted human teeth demonstrate the feasibility of the approach. (Abstract) Keywords-component; Raman spectroscopy; integrated optics;
متن کاملShedding new light on early caries detection.
Dental caries continues to be a common chronic disease among various population groups. Patient care can be improved with detection at the earliest stage. However, current techniques do not have sufficient sensitivity and specificity. We discuss 2 new methods - optical coherence tomography (OCT) and polarized Raman spectroscopy (PRS) - that are potentially useful for early caries detection and ...
متن کاملDetection and Characterization of Human Teeth Caries Using 2D Correlation Raman Spectroscopy
Background: Carious lesions are formed by a complex process of chemical interaction between dental enamel and its environment. They can cause cavities and pain, and are expensive to fix. It is hard to characterize in vivo as a result of environment factors and remineralization by ions in the oral cavity. Objectives: The development of a technique that gives early diagnosis which is non-invasi...
متن کاملDetermining the Effect of Calculus, Hypocalcification, and Stain on Using Optical Coherence Tomography and Polarized Raman Spectroscopy for Detecting White Spot Lesions
Optical coherence tomography (OCT) and polarized Raman spectroscopy (PRS) have been shown as useful methods for distinguishing sound enamel from carious lesions ex vivo. However, factors in the oral environment such as calculus, hypocalcification, and stain could lead to false-positive results. OCT and PRS were used to investigate extracted human teeth clinically examined for sound enamel, whit...
متن کامل